The film is the fourth feature film directed by Olivier Megaton, and it mainly travels between five cities: Paris, Chicago, Miami, New Orleans and Mexico. Catalia Restrepo (Zoe Saldana) witnessed her parents being brutally killed by Colombian drug lord Don Luis at the age of ten. Catalia, who escaped from the dead, fled to Chicago and joined her uncle Emilio, who was also a gangster. Emilio tried his best to keep Calaleja away from the influence of gang life, but Catalia wanted to become a professional killer. At the age of 25, she finally became an experienced and ruthless assassin. She usually works for her uncle Emilio, but her inner goal is to avenge her parents and kill drug tycoon Don Luis. Nothing can stop Catalina from seeking revenge, no matter her uncle Emilio or the FBI or CIA officials. Although Catalina feels guilty for the murder of her uncle Emilio and his family, she is more determined to seek revenge, and also puts drug tycoon Don Luis and his accomplices in fear of death...